What is HUS?

Hemolytic uremic syndrome, caused by sepsis (mainly E.coli O157:H7, bacterial toxins cause endothelial damage, leading to formation of plt microthrombi and thrombocytopenia Mostly in children, similar to TTP but more renal involvement/failure. Tx supportive dialysis until renal function returns (most recover w/in few weeks, some develop chronic renal failure)