How is manifestation of sickle cell anemia?

Acute manifestations Infection, anemia and vaso-occlusion (life-threat) Infection (encapsulated bacteria), acute vasooclusion pain may be accompanied with other complications (stroke, renal infarction, acute chest syndrome, priapism, bone infarct, osteomyelitis (salmonella) Complications related to pregnancy. Chronic manifestations chronic organs ischemia and infarction exacerbated with iron overload Chronic pain, seizure disorder, pulmonary HTA, asthma, hypoxemia, renal impairment and HTA, osteoporosis (bone infarct), cardiamyopathy (diastolic), hepatic injury, delayed puberty, reduced growth, chronic leg ulcers, proliferative retinopathy Spleen frequently affected (infarcted in childhood (autosplenectomy) recommended Abx and vax