What are SSRIs?

Fluoxetine, sertraline, paroxetine, fluvoxamine, citalopram, escitalopram. Mode of action (at begining serotonin increases in somatodendritic area in midbrain raphe causing side effects, over time auto receptors downregulate and become desensitized, serotonin release isn't turned off increasing their release and neural impulse flow so therapy w/tolerance to side effects Side effects (CNS [nervousness, insomnia, fatigue, headache, tremor], GI [nausea, vomit 14%, diarrhea constipation, increased apetite and weight gain], sex [delayed orgasm, decreased libido], endocrine [DM], pregnancy [Fluoxetine OK others no data])