How is course and comorbidities of MDD?

5 Rs of mental illness: after an episode, the patient gets response (better), then remission (stops episode) then relapse (another episode), then Recovery (complete resolution) then recurrence (after total recovery) Usually recurrence risk increases with episode numbers (1st episode: 50%, 2nd 70%, 3rd >90%) Comorbidities (CAD1 18% w/episode, MI 16% 6 months post MI, Cancer during illness 20-25%, HIV 1 year 36%, migraine lifetime 22-32%, alzheimer in episode 17-31%, MS lifetime up to 50% Depression in patients in 2 times more than normal individuals, up to 30% in acute hospitalized pt.