Acne Vulgaris Pathophysiology (step by step)

1 Acne results from obstructed sebaceous follicle (microcomedone) 2 Cells adhere to each other; forms dense keratinous plug 3 Sebum becomes trapped behind keratin plug 4 sebum solidifies; forms OPEN or CLOSED comedone 5 Pooling of sebum increases Anaerobic Bacterium Propionibacterium acnes; generate T cell response; results to inflammation