How is synovitis and pro-inflammatory molecules?

 Products of cartilage breakdown are released into the synovial fluid and are phagocytosed by synovial cells, amplifying synovial inflammation  activated synovial cells in the inflamed synovium produce catabolic and proinflammatory mediators that lead to excess production of the proteolytic enzymes responsible for cartilage breakdown, creating a positive feedback loop  In addition to these effects on cartilage inflammation and breakdown, the inflamed synovium contributes to the formation of osteophytes via BMP