Pregunta:
How is physiopathologic cycle of gout?
Autor: H KRespuesta:
Intercritical gout is quiecent, then comes urate crystal recognition by phagocytes, that release inflammasomes (IL1beta, IL6, IL18, TNF alpha, IL10) then amplification phase due to tissue damage, matric metalloproteinases, PGs, TLRs, then comes resolution phase (anti-inflammatory mediators like CD68, PPAR, TGF)
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Autor
H K