Usually the result of the study may be limited when the circumstances of a particular studies such as patient characteristics or the technique of delivering a treatment, the setting of care differ from the circumstances of the rest. the extent to which the result of the study conducted under a particular circumstance can be generalized to other patients or population. chatgpt explained: For instance, if a study is conducted on a specific group of people, the question becomes whether the findings of that study can be applied to a broader population beyond the group studied.