DIRECT ACTION OF THE TOXIN 1 → Chelation (heavy metals) → immunotherapy (digoxin) → Bio scavenger therapy (Organophosphorus compound) 2 → Activated charcoal → Intra-lipid (lipophilic Local Anesthetics and nonLA drugs) → Enhanced elimination → Hemadsorption: resin/charcoal based urinary alkalinization (salicylates, phenobarbital)