What are the actions of nicotine as ganglionic blocker?

CNS (highly lipid soluble readily crosses BBB, low doses produces euphoria and arousal as well as relaxation. Improves attention, learning, problem solving, and reaction time. High doses lead to central respiratory paralysis, it is also an apetite suppressant.) Peripheral effects as ganglionic blockade (stimulates sympathetic, adrenal medulla and parasympathetic, increase BP and HR, so harmful in HTN pt, induce vasoconstriction decrease coronary blood flow, affecting patients with angina, increase peristalsis, secretions by parasympathetic ganglia Higher doses BP falls, activity of GI and bladder ceases due to block of parasympathetic_