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Pharmacology

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Pregunta:

What are pharmacokinetics and adverse effects of atropine?

Autor: H K



Respuesta:

Pharmacokinetics (readily absorbed, partially metabolized by liver, eliminated by urine) Adverse effects (depends on dose, dry mouth, blurred vision, tachycardia and constipaton. CNS effects (restlessness, confusion, hallucinations, and delirium which may progress to depression, collapse of CV and respiratory system, and death Low doeses of anticholinesterases may be used to overcome atropin toxicity) It is generally available as sulfate salt can be admin IV, SC, IM, ophthamic, oral but only in combination with other products Effects from 0.5 mg (some dryness), 1 mg (accelerated HR and mild pupil dilation), 2 mg (palpitation, dilated pupils, blurring) , 5 mg (difficulty speaking/swallowing, restessness fatigue, dry hot skin), 10 mg (pulse rapid weak, hallicination , delirium, coma)


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Autor

H K
H K