How are anti-cholinesterases as indirect acting cholinergic agonists?

Inhibitors of acetylcholinesterase prolong lifetime of acetylcholine resulting in accumulation of acetylcholine in synaptic space. Provoke a response in cholinoreceptors in body including ANS muscarinic and nicotinic receptors, neuromuscular junctions and in the brain They are intermediate/ short-acting drugs with reversible effects Include Physostigmine, Neostigmine, Edrophonium, Tacrine, Pyridostigmine, Donepezil, Rivastigmine, Galantamine