How is air pollution effect?

Significant cause of M&M in risk pt (pulmonary/cardiac disease), causes include microorganisms and chemical and pollutants. Air pollution (industrialized countries air (ozone, SO2, acid aeosols, particles <10micm), indoor tobacco smoke CO, NO2 and asbesots. Ozone made of NO and volatile organic compounds (emissions of cars..), ozone toxicity mediated by production of free radicals injuring epithelia of respiratory tract and Type I alveolar cells and cause release of inflammatory mediators, causing URT inflammation and variable symptoms (asthma, emphysema) Most harm done by particles <10micm inhaled and go to alveoli cause inflammation by macrophage and neutrophils rxn (e.g Anthracose)