F. TOXICITY RESULTING FROM DYSREPAIR 3) Carcinogenesis ; a) Failure of DNA Repair: Mutation, the Initiating Event in Carcinogenesis 1 If lesions are NOT REPAIRED or injured cells are NOT ELIMINATED, a LESION IN THE PARENTAL DNA STRAND may induce a __in the daughter strand during replication. 2 are HIGHLY CONSERVED genes encoding proteins that stimulate progression of cells through the cell cycle.