Pregunta:
How is differentiation and anaplasia characteristics of benign and malignant tumors?
Autor: H KRespuesta:
How much does neoplasm resemble original cells, if no differentiation: Anaplasia, benign neoplasms resemble normal cells (lipoma, chondroma), rare mitosis and normal configuration, malignant have morphologic alterations, some neoplasms are malignant though well-differentiated (like thyroid adenocarcinoma seen by invasion malignant), no difference in stroma, tumors of undifferentiated cells in anaplatic malignancy, loss of function of differentiated normal cells) Anaplasia (pleomorphic, nuclear abnormalities, tumor giant cells, atypical mitosis, loss of polarity) Functional properties are sustained in well-differentiated tumors while anaplastic are less likely to have function, endocrine tumors differentiated increase secretion, skin increase keratin, hepatocellular secrete bile, some produce fetal proteins (unanticipated), non-endocrine may produce ectopic hormones (paraneoplastic)
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