Pregunta:
How is iron absorption in small bowel regulated?
Autor: H KRespuesta:
Enhanced absorption (seen in iron deficiency, increase erythropoiesis, dietary factors are ascorbic acid (Vit C) and heme vs. nonheme Fe) Inhibited absorption (seen in increased iron stores, cause inflammation, dietary factors are tannins (tea) and phytates (bran)) Regulation of metabolism by hepcidin (which increases Fe storage in macrophages and decrease it in blood and absorption by hepatocytes by binding ferroportin on macrophages and enterocytes degrade them, increased activity in case of inflammation and increased Fe, decreased in case of increased hemopoiesis and Fe deficiency
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