How is repair by scarring?

If regeneration not sufficient, replacement of cells by CT occurs leading to scar formation, severe injury/ chronic injury, patches not restorage of tissues) Steps are hemostatic plug and inflammation 6 min -48 hours of injury, proliferation of cells up to 10 days (eschar form), then remodeling to produce fibrous scar 2-3 weeks and up to months/ years Macrophages are central cellular players, clear microbes and promote inflammation, produce GF leading to cell proliferation, lead to epithelial cell proliferation, angiogenesis (endothelia) and fibroblast proliferation make scar lay down collagen (form granulation tissue which is pink, soft, granular gross appearance beneath scab of a skin wound) So healing is two types, first intension (all regeneration) and second intension (scar and regeneration)