What are cells and mediators of chronic inflammation?

Macrophages (secrete cytokines and GF, destroy foreign invaders, activate lymphocytes. Monocyte entry to tissues by adhesion molecules and chemokines, half-life of monocyte is 1 day while macrophage is years, and becomes dominant in inflammation w/in 48 hours make mononuclear phagocyte system, made in bone marrow and liver in embryo/yolk sac) Eosinophils (IgE and parasitic reactions, adhesion molecules driven, have major basic protein toxic to parasites but injures epithelia, so can contribute in tissue damage by allergies) Mast cells (both acute and chronic inflammation, bone marrow, similar to basophils but not arise from them, roles like basophils, HS reactions, IgE bound, release mediators like histamine and PGs (allergies to food/venum), secrete plethora of cytokines promote chronic inflammation) Neutrophils (usually acute, but can be chronic for months, induced by chemokines and mediators by macrophage and T cells, in osteomyelitis can persist for months, COPD)