How is pathogenesis of ICD?

Resident epidermal cells, endothelial cells, leukocytes interact under control of cytokines and lipid mediators. Keratinocytes initiate skin inflammatory reactions through cytokine release, environmental factor stimulates release of inflammatory cytokines (IL1, TNF-a), chemotactic cytokines (IL8/10), Growth-promoting cytokines (IL6,7,15,TGF-a), humoral vs cellular immunity cytokines (IL10/12/18), ICAM-1 infiltration of leukocytes.