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Endocrinology

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Pregunta:

How is pathophysiology of insulin resistance?

Autor: H K



Respuesta:

Increased free fatty acid, lead to increase glucose production in liver and decreased glucose uptake (glycogen), leads to increased insulin secretion, less insulin sensitivity (muscle), increased Na+ reabsorption causing HTN. Another path is increased proinflammatory cytokines by adipose leading to increased FFA and same mechanism above. Dangers caused by insulin resistance include hyperinsulinemia, IGT, Dyslipidemia, HTN, coagulopathy.


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Autor

H K
H K