What is MEN 1?

Auto dominant inactivation of MENIN gene on chromosome 11, high penetrance for PHPT which is usually initial presentation of the disease, 90-95% of pt w/MEN 1 develop PHPT often at younger age than usual, multiple gland disease in this case so we need subtotal/total parathyroidectomy w/autotransplantation, pt can also have pituitary lesions.