What are clinical features of PBC?

Asymptomatic (30% of pt, elevated ALP and AMA, hyperlipidemia) Symptomatic (fatigue 90%, pruritis 70%, hyperpigmentation 55%, hepatomegaly 50%, jaundice and splenomegaly 30%, xanthelasma 20%) Associated diseases include (keratoconjunctivitis 72-100%, CREST 78%, Cutaneous disorders (lichen, lupus, pemphigoid 50-80%), arthritis 4-42%, scleroderma 20%, raynaud disease 20%, AI thyroiditis 11%, renal acidosis gallstones 33%)