What are lab studies done in AIH?

Autoantibodies (90% of cases should be positive, for AIH Type I ASMA and ANA +, for Type II anti LKM 1 +) Serum protein electrophoresis and quantitative Igs (IgG predominance polyclonal, gamma globulin from 3 to 6 g/dl, most of the cases we have hypergammaglobulinemia and we see the levels of them to see response to therapy) Liver chemistries (AST-ALT elevated in all pt initial presentation (200-300 U/L) and can continue to increase w/inflammation, Serum Bi-ALP mild to moderate increase in 80-90% of pt, reflect PSC or onset of hepatocellular carcinoma due to cirrhosis) Mild leukopenia, normochromic anemia, Coombs+ hemolytic anemia, thrombocytopenia, elevated ESR, eosinophilia (may also be present)