How is the invasion of pancreatic cancer?

Head tumors can obstruct common bile duct and pancreatic duct, leads to jaundice and chronic obstructive pancreatitis. We see duct dilation, fibrous atrophy of pancreatic parenchyma. Some tumors can involve ampulla of vater/ duodenum, and retroperitoneal tissue involvement is almost always present at time of dx can result in invasion of SMA and nerves/portal vein. Neoplasms of tail can cause invasion of spleen, stomach, splenic flexure of colon or left adrenal gland, if advanced metastasis to lymph nodes, liver and peritoneum are common. Also pleura and lungs and bone are less commonly involved