Pregunta:
How is TB type IV hypersensitivity and Caseating granuloma formation?
Autor: H KRespuesta:
As a delayed hypersensitivity rxn, TB stimulates immune cells (CD4+ T, macrophages using IFN-gamma), form multinucleated giant cells and formation of epithelioid cells, these cells aggregate around mycobacteria and form granuloma. Epithelioid cells are macrophages forming cytokines which merge together to form giant cells (tuberculoid granuloma) IL4, IFN-g, IL6, TNF-a form this granuloma, Caseous (cheese-like) granuloma, explained by mycolic acid of mycobacterium cell wall (necrosis of granuloma forms caseating necrosis which presents as a central area of uniform eosinophilia on H&E stain)
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