What are the etiologies of IPF?

Unknown cause, environment play a role, more current in smokers (increases risk by 3.6 times with familial cause) Six exposures associated with it (smoking, farming, livestock, wood dust, metal dust and stone/sand Chronic GERD may be a factor (fibrosis is complication of scleroderma involving esophageal dysmotility) Genetics important (noted in 0.5-3.7% of pt)