How is the pathophysiology of HepB?

Chronic: 10-30% are symptomatic (fatigue most common) Acute flares (similar to acute hep), extrahepatic manifestations (polyarteritis nodosa, cyroglobulinemia and glomerulonephritis) May have abnormal liver chemistry levels, inflammatory liver biopsy May be HBeAg positive or negative If positive (active replication, DNA >2 x104 if negative (precore mutation, HBeAg not produced)