-TARGET THE 50S SUBUNIT -TREAT MAINLY GRAM-NEGATIVE, but has (+) coverage: ○ Pseudomonas- gram-negative bacteria. ○ certain typed of Aerobic gram-negative bacteria ○ Enterobacteria- gram-negative MOA: transfer RNA is carrying specifically the ANTICODON complimentary to the codons. and then they're carrying a SPECIFIC AMINO ACID that's specific to those codons. BLOCKS THE tRNA that goes to the A site CAN TREAT: ○ URINARY TRACT INFECTIONS ○ PNEUMONIA ○ MENINGITIS ○ PERITONITIS