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Pharmacology

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Pregunta:

Give an example of acetylation.

Autor: H K



Respuesta:

Isoniazid (INH) chemotherapy tx of TB, primary step of its metabolism is acetylation by (NAT2) forming acetyl-INH. So we have fast acetylators and slow ones which will affect the half life of the drugs, causing higher risk of drug toxicity for slow acetylators due to higher half-lifes.


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Autor

H K
H K