What is glucuronide conjugation?

It is one of the major pathways of elimination of lipophilic xenobiotics. Involves reaction of functional groups with a sugar derivative (endogenous product) uridine 5-diphosphoglucuronic acid (UDPGA). Enzyme involved is UDP glucuronosyl transferase (UGT) found in liver microsomes (it is the only conjugated enzyme in microsome, rest are in cytosol). These products can be excreted largely in bile and hydrolyzed to aglycone by intestinal flora