SYNTHESIZED IN THE LIVER, it is THE MOST IMPORTANT PROTEIN that binds to drug molecule due to its high concentration compared with other proteins MAJOR COMPONENT of plasma proteins RESPONSIBLE FOR REVERSIBLE DRUG BINDING WEAK ACIDIC(ANIONIC) and NEUTRAL COMPOUNDS will tend to BOND WITH IT 5% OF THE TOTAL PLASMA RESPONSIBLE FOR MAINTAINING THE OSMOTIC PRESSURE of the blood and for the transport of endogenous and exogenous substances