What is necrosis?

It is a pathway of cell death, where cytoplasmic membranes are damaged releasing toxins to the cell. Cytoplasm gets more eosinophilic, more glassy appearance due to glycogen loss, increased myelin figures, vacuolated month-eaten cytoplasm due to organelle digestion by enzymes Nuclear changes are karyolysis (no more basophilia due to DNA damage), pyknosis (nuclear shrink due to DNA decondesation), karyorrhexis (fragmented nucleus) 1-2 days nucleus disappears