What are the risk factors that give RA?

Genetics (60% heritability, ACPA + or HLADR4/DR1, it is a polygenic disease) Smoking (most common factor, more difficult, erosive and severe RA, induces protein citrullation) Periodontal disease (oral flora imp to take care of oral hygiene) Other factors (coffee, mineral oils, silica dust, alcohol, pregnancy)