• also used as the free acid, Valproic Acid • MOA: blocks high-frequency firing of neurons, modifies amino acid metabolism • Very effective against ABSENCE SEIZURE and is often PREFERRED when the patient has CONCOMITANT GENERALIZED TONIC-CLONIC ATTACKS Myoclonic seizures Generalized Tonic-Clonic Seizures MANAGEMENT OF BIPOLAR DISORDER MIGRAINE PROPHYLAXIS