Systemic risk factors for dental disease

Is it something/risk factor that is increasing the risk of periodontal disease from their physical or general health (happening within the whole body, like other conditions, (E.g., heart disease, diabetes), is it that their immune response to the oral diseases is weakened because of their underlying general health issues. Diabetes Stress Hormonal fluctuations (puberty, pregnancy, menopause) Metabolic syndrome (high blood pressure, excess body fat, abnormal cholesterol) HIV/AIDS Neutropenia Down syndrome Leukemia