Allopurinol: -Indication -Dose -Side effects -Interactions

-Long term Gout (Xanthine-oxidase inhibitor) -100-300mg daily (2-3 weeks after attack has settled)- initial management (Nsaids/ Colchicine)- renal dose in renal impairment -Rash (stop (mild) reintroduce- reaccurnace (Immediately stop)- Allergy -Interacts with axiothioprine (metabolised by xanthine-oxidase)- toxcitiy of axiothiopurine.