Gallbladder problems start when the liver is so overloaded with intestinal toxins that they get dumped into the duodenum or gallbladder before they are fully neutralized. These toxins, if left simmering in the gallbladder, can cause so much irritation that the gallbladder begins to malfunction. If the gallbladder doesn't secrete bile properly, the fats and minerals in the bile can become stones. The most common symptom associated with gallbladder trouble is feeling worse after eating fatty foods.