First-Generation Cephalosporins: Dosage/Route: Adult: 250-500 mg intramuscular (IM) or intravenous (IV) q4-8h; reduce dose in renal impairment. Pediatric: 25-50 mg/kg/d IM or IV in three or four divided doses Usual Indications: Treatment of respiratory tract, skin, genitourinary (GU), biliary tract, bone, joint, and myocardial infections, as well as sepsis.