Stamp Out Sleeping Sickness (SOS) Initiative

Early stage disease 1st line drug: uramin efficacious against T b rhodesiense. Pentamidine efficacious against T b gambiense. Pentamidine is not effective against early stage T b rhodesiense. Late stage disease: Melarsoprol efficacious against both. Late stage treatment failures of T b gambiense increasing. An alternative is Eflornithine but is not effective against T b rhodesiense.