Human Genetic Analysis

Families Linkage Studies: Simple inheritance, Single gene with major effect, Variant allele rare in population, Alleles in causative gene co-segregate with the trait, Mendelian ratios not observed due to small sample sizes. Populations Association Studies: Complex Inheritance, Multiple genes with small contributions and environmental contexts, Variant allele(s) common in the population, Looking for alleles enriched in the case group.