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MCB L19-20

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Pregunta:

MOMP - Mitochondrial outer membrane permeabilization

Autor: Alex Rapai



Respuesta:

Proteins of BH3 family activate BAK/BAX to form channels in outer membrane cause MMP BH3 proteins can also inhibit antiapoptotic factors (BCL-2 proteins), liberating BAK/BAX activation. BH3-only proteins include: BID (activated by extrinsic) and BAD (activated by intrinsic)


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