The unfolded protein response (UPR): the ER as a stress sensor

The protein folding capacity of the endoplasmic reticulum (ER) is tightly regulated by a network of signalling pathways - the unfolded protein response (UPR). UPR sensors monitor the ER folding status of proteins in the ER. Following sensing, the UPR adjusts the folding capacity of the ER according to need