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LF263 Evolution L13-14

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Pregunta:

Human accelerated regions (HARs)

Autor: Alex Rapai



Respuesta:

Previous examples focused on amino acid changes A study scanned entire genome for phylogenetic branch lengths longer in humans compared to chimpanzee, rat and mouse 49 HARs identified, 96% were non-coding RNAs, 24% were adjacent to neurodevelopmental genes HAR1 most significant, involved in cortical development: 18 substitutions occurred where 0.27 expected


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