Describe the P14IN4a/CDK4/RB1 pathway in cancerous cells.

In the case of cancer, the incorrect or underexpression of People 16INk4a tumour supressor, means that there is no recombination of the RB and E2F proteins, meaning that proliferation is signalled to continue. CDK4/6 inhibitors are therefore, an area of cancer treataent being used in underexpression of p16INk4a. Overexpression of CDK4/6/Cyclin D can also lead to cancer development as overproliferation occurs.