Genreal cardiovascular health:reduces cholesterol level:topical application produces analgesia, controls bleeding topical application as a counterirritant produces a "heat" sensation repeated applications produce analgesia that results from neuronal depletion of substance P (a mediator of pain transmission between peripheral nerves and spinal cord). Burning drug interactions exist with ACE inhibitors, heparin, ASA, disulfiram, and theophylline. herb interactions exist with feverfew, garlic, ginger, and ginseng.