Cardiac: Increase risk of AS, pericarditis, myocarditis, valve nodule Lung: Pleurisy with effusion diffuse Interstitial fibrosis Renal : Amyloid renal dz Blood: anemia of chronic dz and neutropenia Vasculitis: Synovial inflammation Nerve: Mononeuritis multiples with foot and wrist drop Skin: rheumatoid nodule