Talk about macrophages.

After passage to tissues, monocytes differentiate into macrophages, size is larger than monocytes, (20 40 microm) cytoplasm is slightly eosinophilic, presents in vacuoles and lysosomes, cytoplasmic extensions that form truw pseudopodia, highly developed cytoskeleton related to extreme mobility of the cell. Involved in all body's major defenses against foreign antigens act by phagocytosis by secretion of toxic substances and triggering immune reactions. They are distinct from the ones present initially at the tissues.