Talk about Dephosphorylation process done by SER.

Takes place in hepatocytes, storing glucose and glycogen, which are granules next to the SER membranes, when body is not supplied with glucose, through the intestine, the liver uses glycogen reserve by glycogenolysis. Phosphorylase adds phosphate to produce glucose-1-phosphate from glycogen which is then isomerized into glucose-6-phosphate, which cannot be released into blood stream, and is kept in the cytoplasm since plasma membrane is not permeable to phosphorylated sugars. SER contains glucose-6-phosphatase that removes phosphate and becomes glucose which can diffuse by pumps, transporter.