Amphotericin B: Nursing Implications

Pre-treat with Benadryl + acetaminophen to reduce “shake and bake” symptoms; Administer IV slowly (2-6 hrs); Monitor cardiovascular and respiratory status during IV therapy; Reduce or discontinue if BUN over 40mg/dL or creatinine over 3 mg/dL; Check vitals every 30 min for 4 hours after test dose