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level: TOXICOLOGY 1 - PESTICIDES

Questions and Answers List

Question	Answer
A pesticide which interferes with the inactivation of sodium (Na+) channels in excitable membranes which results to repetitive firing of neurons	Organocholrine
Calcium ion transport is inhibited, which affects the "repolarization" of the neuron = INCREASED NEURON EXCITABILITY	Organochlorine
Major effect of Organochlorine	CNS Stimulation
Chronic exposure to Organochlorine	Enhanced carcinogenesis
The major effect of this pesticide is INHIBITION of ACETYLCHOLINESTERASE via PHOSPHORYLATION of esteratic site	Organophosphorus
This pesticide produces DIRECT CHOLINERGIC activity	Organophosphorus
Antagonist of Organophosphorus - because it binds to organophosphate-inactivated acetylcholinesterase.	Pralidoxime
Associated with PARALYSIS & AXONAL DEGENERATION	Organophosphorus Ester-induced Polyneuropathy
Progressive demyelination of long nerves	Organophosphorus
Inhibit acetylcholinesterase via CARBAMOYLATION	Carbamates
TRUE / FALSE: The signs & symptoms of Carbamate poisoning are shorter compared to Organophosphorus poisoning	True - reactivation of cholinesterase is faster
TRUE / FALSE: PRALIDOXIME is a recommended treatment for CARBAMATE poisoning	FALSE